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Check out the latest DOTE issue for articles on Benign Esophageal and Malignant Esophageal Diseases.

Myotomy in sigmoid megaesophagus: is it applicable? A systematic review and meta-analysis
Editor's Choice - Free Article
Achalasia is a rare esophageal primary motor dysfunction with no cure. The aim of the achalasia therapy is to palliate the symptoms, mainly dysphagia. Its treatment usually focuses on inferior esophageal sphincter disruption, leading to facilitated food transit to the stomach. It can be done by surgical myotomy or endoscopic procedures, such as cardia dilatation or peroral endoscopic myotomy (POEM). Read the full article.

Severity of GERD and disease progression
Editor's Choice - Free Article
Many factors may play a role in the severity and progression of gastroesophageal reflux disease (GERD) since pathophysiology is multifactorial. Data regarding the progression of GERD are controversial: some reports of increased esophageal acid exposure (EAE) and mucosal damage were considered as evidence for a stable disease course, while others interprete these findings as disease progression. The aim of this study is to analyze a large patient-population with persisting symptoms indicative of GERD under protonpumpinhibitor-therapy and identify components characterizing disease severity and progression. Read the full article.

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