Population: adults over 18 years with a diagnosis of Barrett’s esophagus with either no dysplasia, indefinite dysplasia or low grade dysplasia (esophagitis alone is not included).Intervention: anti-reflux surgery, endotherapy, proton pump inhibitors, aspirinComparator: surveillance or no actionOutcome: What outcomes should be measured for therapy (lack of progression, regression to non-dysplastic or neo-squamous mucosa, 5 year survival and overall survival)?
to use a Delphi mechanism process to produce iterative changes for producing an evidence-based consensus such as done previously for the management of dysplastic Barrett’s (BAD CAT). This process is accredited by NICE (UK) and we will adopt the methods for BOB CAT. We will use a specially designed internet platform to vote on statements and review evidence.
|Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process||Cathy Bennett, Nimish Vakil, Jacques Bergman, Rebecca Harrison, Robert Odze, Michael Vieth, Scott Sanders, Laura Gay, Oliver Pech, Gaius Longcroft–Wheaton, Yvonne Romero, John Inadomi, Jan Tack, Douglas A. Corley, Hendrik Manner, Susi Green, David Al Dulaimi, Haythem Ali, Bill Allum, Mark Anderson, Howard Curtis, Gary Falk, M. Brian Fennerty, Grant Fullarton, Kausilia Krishnadath, Stephen J. Meltzer, David Armstrong, Robert Ganz, Gianpaolo Cengia, James J. Going, John Goldblum, Charles Gordon, Heike Grabsch, Chris Haigh, Michio Hongo, David Johnston, Ricky Forbes–Young, Elaine Kay, Philip Kaye, Toni Lerut, Laurence B. Lovat, Lars Lundell, Philip Mairs, Tadakuza Shimoda, Stuart Spechler, Stephen Sontag, Peter Malfertheiner, Iain Murray, Manoj Nanji, David Poller, Krish Ragunath, Jaroslaw Regula, Renzo Cestari, Neil Shepherd, Rajvinder Singh, Hubert J. Stein, Nicholas J. Talley, Jean–Paul Galmiche, Tony C.K. Tham, Peter Watson, Lisa Yerian, Massimo Rugge, Thomas W. Rice, John Hart, Stuart Gittens, David Hewin, Juergen Hochberger, Peter Kahrilas, Sean Preston, Richard Sampliner, Prateek Sharma, Robert Stuart, Kenneth Wang, Irving Waxman, Chris Abley, Duncan Loft, Ian Penman, Nicholas J. Shaheen, Amitabh Chak, Gareth Davies, Lorna Dunn, Yngve Falck–Ytter, John Decaestecker, Pradeep Bhandari, Christian Ell, S. Michael Griffin, Stephen Attwood, Hugh Barr, John Allen, Mark K. Ferguson, Paul Moayyedi, Janusz A.Z. Jankowski||Gastroenterology - August 2012 (Vol. 143, Issue 2, Pages 336-346, DOI: 10.1053/j.gastro.2012.04.032 )|